A prospective study of HLA-B*1502 genotyping in preventing carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis
Pei Chen1, Chen-Yang Shen1, Juei-Jueng Lin2, Cheung-Ter Ong3, Shey-Lin Wu4, Yuan-Tsong Chen1, and Taiwan SJS consortium. 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Chu Shang Show Chwan Hospital, Nan-tou, Taiwan; 3Chia-Yi Christian Hospital, Chia-Yi, Taiwan; 4Changhua Christian Hospital, Chang-Hua, Taiwan.
Stevens-Johnson syndrome (SJS) and its related disease toxic epidermal necrolysis (TEN) are two of the most serious adverse reactions caused by drugs. Carbamazepine (CBZ), used primarily in the treatment of epilepsy and bipolar disorder, is the commonest cause of SJS/TEN in
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