Welcome to TAIWAN ACGA 2010 Program

May 2 (Sunday)
4:30-6:30 pm	Registration [3F]
6:30-8:00 pm	Welcome Reception [4F, Recreation Hall]

May 3 (Monday)
8:45-9:00 am	Opening Remarks [3F, International Conference Hall] Stephen T.S. Lam, President, Association of Chinese Geneticists in America Yuan-Tsong Chen, Chairman, Taiwan-ACGA 2010 Organizing Committee
9:00-10:00 am	Keynote Speech I [3F, International Conference Hall] Moderator: Pan-Chyr Yang, President, Taiwan Genomics and Genetics Society Mark McCarthy, Churchill Hospital, UK Type 2 Diabetes genetics: the end of the beginning or the beginning of the end?
10:00-10:15 am	Coffee Break
10:10am-12:10 pm	Concurrent Session Population Genetics Chairs Cathy Fan, Academia Sinica, Taiwan Nelson Tang , Chinese University of Hong Kong, HK Speakers Modeling expression quantitative trait loci in data combining ethnic populations Cathy Fan, Academia Sinica, Taiwan Population genetics of gene expression and disease causing mutations Nelson Tang , Chinese University of Hong Kong, HK Li Jin, Fudan University, China Graves’ disease is associated with a distinct spectrum of HLA alleles in Asian populations Pei-Lung Chen, National Taiwan University, Taiwan Clinical Genetics Chairs Paul Hwu, National Taiwan University, Taiwan Stephen Lam, Department of Health, Hong Kong Speakers Lysosomal Storage Disorders: complementary role of biochemistry and molecular genetics in laboratory diagnosis and management of patients and families Marie Vanier, INSERM, France Congenital myasthenic syndromes: from patient to bench and back Margherita Milone, Mayo Clinic, USA Diseases Involved in Loss of Mitochondrial DNA Integrity Lee-Jun Wong, BaylorCollege of Medicine, USA Studies of multiple malformations in Chinese Stephen Lam, Department of Health, HK
12:10-1:30 pm	Lunch/ Company Lunch Seminar
1:30-2:30 pm	Keynote Speech Engineering of Human Pluripotent Stem Cells by AAV-Mediated Gene Targeting David Russell, University of Washington, USA
3:00-5:00 pm	Concurrent Session Genetic Therapeutics Chairs Mi-Hua Tao, Academia Sinica, Taiwan Weidong Xiao, Temple University, USA Speakers Pathways toward Gene Therapy for Hemophilia using recombinant AAV vectors Weidong Xiao, Temple University, USA Use of RNA Interference to Modulate Liver Adenoma Development in A Murine Model Transgenic for Hepatitis B Virus Mi-Hua Tao, Academia Sinica, Taiwan Novel AAV vectors and strategies for the potential gene therapy of hemophilia A and hemophilia B Arun Srivastava, University of Florida, USA Transgenic human a-hemoglobin stabilizing protein could partially relieve bIVS-2-654-thalassemia syndrome in model mice Yudan Fang, Shanghai Jiao Tong University School of Medicine, China Efficient Axonal Transport-Based Gene Delivery Provides Therapeutic Correction in Murine Globoid Cell Leukodystrophy DarShong Lin, Mackay MemorialHospital, Taipei, Taiwan Prenatal and Pre-implantation Diagnosis & Screening Chairs Hong-Nerng Ho, National Taiwan University, Taiwan Tao Sheng Huang, University of California, Irvine, USA Speakers Advancement of prenatal screening and prenatal diagnosis in USA Tao Sheng Huang, University of California, Irvine, USA Molecular Karyotyping by array CGH in uncultured CVS: a new horizon for prenatal Diagnosis Richard Choy, Prince of Wales Hospital, HK Prenatal and Pre-implantation Diagnosis & Screening in Taiwan Yi-Ning Su, National Taiwan University, Taiwan Prenatal Sonographic Diagnosis ofFetal Anomalies of Aortic Arch System Shengli Li, Shenzhen, China

May 4 (Tuesday)
9:00-10:00 am	Keynote Speech Rare and common variants in human disease and drug response David Goldstein, Duke University, USA
10:10am-12:10 pm	Concurrent Session Pharmacogenetics Chairs YT Chen, Academia Sinica, Taiwan David Goldstein, Duke University, USA Speakers PharmGKB: The Pharmcogenomics Knowledge Base Teri Klein, Stanford University, USA The genotype-phenotype relationship of severe cutaneous adverse drug reactions Wen-Hung Chung, Chang Gung Hospital, Taiwan From Personalized Medicine to Personalized Justice: A complicated road map to interpretation and application of Pharmacogenomics in the Justice System Michael A. Wagner, Indiana University, USA The role of HLA-B1502 in carbamazepine-induced Stevens-Johnson syndrome Chun-yu Wei, Academia Sinica, Taiwan Health Care Savings from Personalizing Medicine of Using genetic testing to prevent carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis Pei Chen, Academia Sinica, Taiwan Medical Genetics Chairs* Fuu-Jen Tsai, China Medical University, Taiwan Yao-Shan Fan, University of Miami, USA Speakers Genetic testing for personalized cancer treatment Yao-Shan Fan, University of Miami, USA Mutation, mosiacism, X-inactivation and sequence variant: Lessons from unusual molecular findings Tian-Jian Chen, University of South Alabama, USA Fragile X-related Disorders Peng Jin, Emory University, USA Molecular structure and differential expression of genes of double minute chromosomes in UACC-1598 and cooperation of target genes in ovarian cancer Songbin Fu, Harbin Medical University, China
12:10-1:30 pm	Lunch/ Company Lunch Seminar
1:30-3:30 pm	Concurrent Session : Molecular Genetics Chairs Jian-Wei Chen, National Chung Hsing University, Taiwan Xue Zhong Liu, University of Miami, USA Speakers The genetic bases for hearing loss among Chinese Xue Zhong Liu, University of Miami, USA Fortune From Mis-Fortune: Disease Gene Discovery Through Chromosomal Rearrangements Cynthia Morton, Harvard Medical School, USA A century-old story of BDA1 Lin He, Chinese Academy of Sciences, China Nanotoxicogenomics Huei-Wen Chen, National Taiwan University, Taiwan Genetic defects underlying congenital generalized hypertrichosis Xue Zhang, Chinese Academy of Medical Sciences & Peking Union Medical College, China Genomic Technologies in the Post Genomic Era Chairs Chia-Lin Wei, Genome Institute of Singapore, Singapore Huanming Yang, Chinese Academy of Sciences, China Speakers Dynamic of Genome Organizations and Epigentetic Networks during Differentiation Chia-Lin Wei, Genome Institute of Singapore, Singapore The Next Generation Sequencing: Today and Tomorrow Huanming Yang, Chinese Academy of Sciences, China Genome-wide mapping of long-range chromatin interactions involved in transcription regulation Yijun Ruan, Genome Institute of Singapore, Singapore Primer Z 4.0: An online high-throughput primer design tool for the next generation sequencing era Adam Yao, Academia Sinica, Taiwan
4:00-6:00 pm	Poster Session
7:00 pm	Banquet

May 5 (Wednesday)
9:00-11:00 am	Concurrent Session Cancer Genetics and Genomics Chairs Pan-Chyr Yang, National Taiwan University, Taiwan Marilyn Li, Tulane University, USA Speakers Clinical Application of Microarray Technology on Hematological Malignancies and Solid Tumor Marilyn Li, Tulane University, USA Battle of the Sexes: the Roles of Y-located TSPY and X-located TSPX Genes in Cell Proliferation, Viral Protein Stability and Tumorigenesis Yun-Fai Chris Lau, University of California, SF, USA The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients Yi-Ching Wang, National Cheng Kung University, Taiwan A study of DNA copy number alternation for lung adenocarcinoma with EGFR mutation comparison Ker-Chau Li, Academia Sinica, Taiwan Complex Disorders Chairs Pui-Yan Kwok, University of California, SF, USA Chen-Yang Shen, Academia Sinica, Taiwan Speakers After GWAS, then what? Pui-Yan Kwok, UCSF, USA Integrating Admixture Mapping and SNP Analysis from the largest Genome-Wide Association Study in U.S. Hispanics: insights from the GALA study Esteban Gonzalez Burchard, UCSF, USA The Role of Interactions in the Genetic Dissection of Common Complex Traits D.C. Rao, Washington University, USA Lesson learned from mapping hypertension genes Wen-Harn Pan, Academia Sinica, Taiwan Genetic and Epigenetic Mechanisms of Parkinson’s Disease Zhuohua Zhang, Central South University, Hunan, China
11:10am - 12:10 pm	Keynote Speech The impact of chromosomal microarray analysis on medical genetics Arthur Beaudet, Baylor College of Medicine, USA
12:10 - 12:30 pm	Closing Remarks